Viral Infections in the Immunosuppressed Panel

IVD CE

Immunosuppression is a decrease in the immune system’s activity or effectiveness. Immunosuppression can happen as a negative reaction to the treatment of other illnesses or as a result of the immunosuppressive effects of some immune system components on other immune system components. Some people who have a weakened immune system, who are immunocompromised are more likely to get sick for a longer period.

Adenovirus (HAdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are major causes of morbidity and mortality in immunosuppressed individuals. After primary infection, these viruses may remain latent and then occur through immunosuppression. Infection is common with seroprevalence rates increasing steadily from 65% among 40 to 49 year olds to 91% in those aged 80 years or older.

Features

Single Tube Master Mix

Internal Control for Each Reaction

Flexible Packaging

Compatibility with Various Systems

Expert Support

Workflow

Technical Specifications

Thermal Protocol Single thermal protocol for all parameters
Sample Typing Whole blood, serum, plasma, bone marrow, amniotic fluid, urine, biopsy material, cerebrospinal fluid, throat/nasal/dermal/eye/genital swab, nasopharyngeal swab, nasopharyngeal aspirate, bronchoalveolar lavage
Shelf Life 18 Months
Channels FAM, HEX/VIC, Texas Red/ROX, Cy5
Shipping / Storage -80°C / -20°C

Viral Infections in the Immunosuppressed Panel Kits

Bosphore Viral Infections in the Immunosuppressed Panel Kit detects and characterizes CMV DNA, EBV DNA and adenovirus DNA human biological samples; serum, plasma, bone marrow, amniotic fluid, urine, biopsy material, cerebrospinal fluid, throat/nasal/dermal/eye/genital swab, nasopharyngeal swab, nasopharyngeal aspirate, bronchoalveolar lavage. Fluorescence detection is accomplished using the FAM, HEX, Texas Red and Cy5 filters.

FAM HEX Texas Red Cy5
CMV EBV Internal Control Adenovirus

An internal control has been integrated into the kit in order to check nucleic acid extraction, PCR inhibition and application errors. Amplification data of the internal control is detected with Cy5 or Texas Red filter as indicated in the table shown above. Internal control can be added either during nucleic acid extraction or PCR step.

Bosphore Viral Infections in the Immunosuppressed Maxi Panel Kit detects and characterizes JCV DNA, BKV DNA, CMV DNA, EBV DNA and adenovirus DNA human biological samples; serum, plasma, bone marrow, amniotic fluid, urine, biopsy material, cerebrospinal fluid, throat/nasal/dermal/eye/genital swab, nasopharyngeal swab, nasopharyngeal aspirate, bronchoalveolar lavage. Fluorescence detection is accomplished using the FAM, HEX, Texas Red and Cy5 filters.

  FAM HEX Texas Red Cy5
Tube 1 /

Box 1

JCV BKV – Internal Control
Tube 2 /

Box 2

CMV EBV Internal Control Adenovirus

An internal control has been integrated into the kit in order to check nucleic acid extraction, PCR inhibition and application errors. Amplification data of the internal control is detected with Cy5 or Texas RED filter as indicated in the table shown above. Internal control can be added either during nucleic acid extraction or PCR step.

Bosphore VIP Quantification Bundle Kit has been designed to detect, discriminate and quantitate cytomegalovirus (CMV), Epstein-Barr virus (EBV/human herpes virus-4/HHV-4) and adenovirus (ADV) DNA in human biological samples including serum, plasma, bone marrow, amniotic fluid, urine, biopsy material, cerebrospinal fluid, throat/nasal/dermal/eye/genital swab, nasopharyngeal swab, nasopharyngeal aspirate and bronchoalveolar lavage. Fluorescence detection is accomplished using the FAM, HEX and Cy5 filters in two PCR tubes.

  FAM HEX Cy5
Tube 1

Box-1

 CMV Internal Control –
Tube 1

Box-2

 Adenovirus (ADV) Epstein-Barr virus (EBV) Internal Control

An internal control has been integrated into the kit in order to check DNA extraction, PCR inhibition and application mistakes. The internal control can be added either during DNA extraction or PCR step.

Bosphore EBV-Adenovirus Quantification Kit has been designed to detect, discriminate and quantitate epstein-barr virus (EBV/human herpes virus-4/HHV-4) and adenovirus (ADV) DNA in human biological samples including serum, plasma, bone marrow, amniotic fluid, urine, biopsy material, cerebrospinal fluid, throat/nasal/dermal/eye/genital swab, nasopharyngeal swab, nasopharyngeal aspirate and bronchoalveolar lavage. Fluorescence detection is accomplished using the FAM, HEX and Cy5 filters in one PCR tube.

FAM HEX Cy5
Adenovirus (ADV) Epstein-Barr virus (EBV) Internal Control

An internal control has been integrated into the kit in order to check DNA extraction, PCR inhibition and application errors. The internal control can be added either during DNA extraction or PCR step.

Bosphore JCV-BKV Detection Kit v2 detects and characterizes JC Virus and BK virus in human biological samples. The analytic sensitivity is 175 copies/ml for JCV and 75 copies/ml for BKV. A region within JCV genome is amplified and fluorescence detection is accomplished using the FAM filter. A region within BKV genome is amplified and fluorescence detection is accomplished using the HEX filter.

An internal control has been integrated into the kit in order to check extraction and PCR inhibition. The amplification data of the internal control is detected with the Cy5 filter. The internal control is added either in extraction or PCR step.

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