Sepsis is the extreme response of the body’s immune system to an infection, which can cause significant tissue damage and organ failure. Globally, it accounts for a large percentage of all deaths. As September is Sepsis Awareness Month, leading up to World Sepsis Day on September 13, raising awareness about this life-threatening condition and the critical importance of rapid pathogen detection is essential.
Time Matters in Sepsis
The progression of sepsis is rapid, and every minute counts. In severe cases progressing to septic shock, the mortality rate reaches 30% to 40%, sometimes in as little as 12 hours. Furthermore, research shows that for every hour of delay in administering effective antimicrobial treatment, survival rates decrease by 7.6% for patients in septic shock. Recognizing symptoms early and initiating rapid pathogen detection are vital steps in reducing the time for appropriate treatment and enhancing patient outcomes.
The Growing Threat of Antibiotic Resistance
The relationship between sepsis and antibiotic resistance poses a significant threat to global health. Resistance can complicate the timely treatment of sepsis, as the rapid mutation of bacteria may be overlooked by conventional testing methods like blood culture. As resistance spreads, treatment options become limited, prolonging illness and increasing mortality rates.
Direct Whole-Blood Molecular Testing
Real-Time PCR methods offer a crucial advantage in the time-sensitive clinical course of sepsis. A recent study published in the International Journal of Molecular Sciences highlights the clinical effectiveness of this molecular approach.
The research indicates that using UNIO B24 Extraction System and UNIO Whole Blood Genomic DNA Extraction Large Volume Kit, integrated with Bosphore Sepsis Panel Bundle Kit, enables direct whole-blood testing in patients with suspected sepsis.
This automated extraction and multiplex Real-Time PCR workflow supports earlier pathogen and resistance-marker detection without waiting for culture positivity.
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Begmyradova, S., Öksüz, L., Aktas, Z., & Öncül, O. (2026). Diagnosing Sepsis and Identifying Bacterial Resistance Genes Directly from Whole Blood Using a Rapid Real-Time PCR System. International Journal of Molecular Sciences, 27(17), 7669.
https://doi.org/10.3390/ijms27177669
By incorporating Bosphore Sepsis Screening Kit and Bosphore ABR Screening Kit, Bosphore Sepsis Panel Bundle Kit targets 32 pathogens and 10 antimicrobial resistance markers in a single workflow. This comprehensive detection capacity helps healthcare professionals quickly identify the underlying cause and resistance profile, supporting effective, timely clinical decisions.
